Mems force sensor array for evaluating the contractility of IPS cell-derived cardiomyocytes

Kenei Matsudaira, Thanh-Vinh Nguyen, K. H. Shoji, T. Tsukagoshi, T. Takahata, I. Shimoyama
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引用次数: 1

Abstract

We report a force sensor array that can measure iPS cell-derived cardiomyocytes (iPS-CMs) contractility with high sensitivity and high temporal resolution. The fabricated device has six piezoresistive cantilevers whose sensitivities were higher than 9.1 × 10−5 nN−1. Using the device, we measured the contraction force of an iPS-CMs layer. As a result, contractile forces ranging from 1 to 12 nN were measured.
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Mems力传感器阵列用于评估IPS细胞源性心肌细胞的收缩性
我们报道了一种力传感器阵列,可以测量iPS细胞来源的心肌细胞(iPS- cms)具有高灵敏度和高时间分辨率的收缩性。该器件具有6根压阻悬臂梁,灵敏度均高于9.1 × 10−5 nN−1。利用该装置,我们测量了iPS-CMs层的收缩力。结果,测量了1至12 nN的收缩力。
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