Clinical outcome of corpus callosotmy for management of drug resistant epilepsy

Abstract

Background : One of most common chronic neurologic disorders is epilepsy, incapability of signi fi cantly reduce percentage of studied cases resistant to all available antiepileptic treatments without producing unacceptable side effects is particularly frustrating. Aim : Aim of the research was to investigate seizure result following corpus callosotomy in relation to extent of resection in pediatric studied cases with Symptomatic generalized epilepsy with normal preoperative brain imaging on MRI Brain. Patients and methods : Research entails prospective analysis of data from 20 pediatric patients who were treated for intractable symptomatic generalized epilepsy by corpus callosotomy. Results : In the patient series, 13 patient suffered from generalized tonic clonic fi tts (56.3%) and 7 patient is multi focal fi tts (43.8%) one of them is Lennox gustate syndrome, no statistically signi fi cant variation ( P value ¼ 0.101) among grade II and grade III studied cases as regard presentation. Conclusion : Corpus callosotomy affords a good outcome for drop attacks, at least 70% of patients will experience free from these attacks, a so it will abolish the harmful effects like bodily injury, limited activity and caregivers ’ dependency. In pediatricstudiedcases,thereisnovariationinresultamongtotalandanterior2/3colostomyexceptsomecasesmaycomplicate intotalcolostomywithdisconnectionsyndrome,butanywaythesecasesshowbetterimprovementthanadultcases.