SARCOIDOSIS: THE SILHOUETTES OF SCIENTIFIC AND PRACTICAL EVOLUTION

E. Khodosh
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Abstract

Since the times of Jonathan Hatchinson, the author of first clinical description of sarcoidosis case, this disease was considered as dermatological one, slowly evolving into multisystem condition, associated with bone cyctosis, respiratory and other systems involvement. Later, due to epidemiology advances, it has become appreciated that sarcoidosis was spread globally, affecting people of all sexes and races. In the recent years, an achievements in different fields, especially biochemistry, genetics, immunology and molecular biology, significantly improved our understanding of this ilness. Each new methodological approach makes a solution of the enigma closer, particularly a still slipping away cause of the disease. The article reflects the major milestones of sarcoidosis history, highlighted by author. Key words: sarcoidosis, history, evolution of views.
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结节病:科学与实践进化的剪影
自第一个结节病临床描述的作者Jonathan Hatchinson时代起,这种疾病被认为是皮肤疾病,慢慢演变成多系统疾病,伴有骨细胞病、呼吸系统和其他系统的累及。后来,由于流行病学的进步,人们认识到结节病在全球传播,影响所有性别和种族的人。近年来,不同领域,特别是生物化学、遗传学、免疫学和分子生物学的研究成果,极大地提高了我们对该病的认识。每一种新的方法都使人们更接近于解开这个谜,尤其是一个仍在逐渐消失的致病原因。文章反映了结节病历史的主要里程碑,作者强调。关键词:结节病,历史,观点演变。
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