{"title":"The neurobiology of post-traumatic stress disorder","authors":"Jonathan I. Bisson","doi":"10.1016/j.mppsy.2009.04.018","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Our understanding of the neurobiology of post-traumatic stress disorder (PTSD) has improved significantly in recent years. Previous work on the development of fear and memory has underpinned subsequent research that has focused on PTSD. It is now well established that specific areas of the brain are key to the development and maintenance of PTSD. These include the amygdala, </span>hippocampus<span> and medial prefrontal cortex, a popular current hypothesis being that the former is overactive in PTSD due to failure of the other areas to regulate its activity sufficiently. In addition to specific areas of the brain, it is now known that hormones and </span></span>neurotransmitters<span> such as cortisol<span> and noradrenaline appear to play major roles in PTSD. This article provides an overview of current knowledge in this area.</span></span></p></div>","PeriodicalId":88653,"journal":{"name":"Psychiatry (Abingdon, England)","volume":"8 8","pages":"Pages 288-289"},"PeriodicalIF":0.0000,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.mppsy.2009.04.018","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychiatry (Abingdon, England)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1476179309000949","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
Our understanding of the neurobiology of post-traumatic stress disorder (PTSD) has improved significantly in recent years. Previous work on the development of fear and memory has underpinned subsequent research that has focused on PTSD. It is now well established that specific areas of the brain are key to the development and maintenance of PTSD. These include the amygdala, hippocampus and medial prefrontal cortex, a popular current hypothesis being that the former is overactive in PTSD due to failure of the other areas to regulate its activity sufficiently. In addition to specific areas of the brain, it is now known that hormones and neurotransmitters such as cortisol and noradrenaline appear to play major roles in PTSD. This article provides an overview of current knowledge in this area.
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