Basal cell carcinoma treated with MTDQ and irradiation.

Z Pollák, J Fodor, V Erdélyi, O Bihari, S Eckhardt
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引用次数: 2

Abstract

Patients with basal cell carcinoma of the skin were treated with combined MTDQ (6,6'-methylene-bis-(2,2,4-trimethyl-1,2-dihydroquinoline)) administration and irradiation. Significantly better results were obtained with a skin exposure of 2 000 R combined with MTDQ than with the same dose alone. The results were comparable to those obtained with an exposure of 4 000 R. MTDQ administration induced decrease of tissular malonaldehyde concentration and suggested the peroxide-decomposing action of the radiation sensitizer.

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MTDQ联合放射治疗基底细胞癌。
皮肤基底细胞癌患者采用MTDQ(6,6′-亚甲基-双-(2,2,4-三甲基-1,2-二氢喹啉))联合给药和照射治疗。皮肤暴露2 000 R联合MTDQ比单独暴露相同剂量获得明显更好的结果。结果与暴露于4 000 r时的结果相当,MTDQ引起组织丙二醛浓度下降,提示辐射敏化剂有过氧化物分解作用。
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