J. Loureiro, M. Coelho, S. Rocha, Maria do Carmo Pereira
{"title":"Design of potential therapeutic peptides and carriers to inhibit amyloid β peptide aggregation","authors":"J. Loureiro, M. Coelho, S. Rocha, Maria do Carmo Pereira","doi":"10.1109/ENBENG.2012.6331364","DOIUrl":null,"url":null,"abstract":"The conformational changes and aggregation of amyloid β peptide (Aβ) are associated to Alzheimer's disease (AD). The aim of this work is to study the structure and fibril assembly of Aβ in the presence of charged and nonionic amphiphiles, and β-sheet breaker peptides/conjugates. It is expected that these molecules will inhibit Aβ aggregation. Liposome systems will be developed as carriers for these peptide conjugates to cross the brain blood barrier (BBB).","PeriodicalId":399131,"journal":{"name":"2012 IEEE 2nd Portuguese Meeting in Bioengineering (ENBENG)","volume":"2 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2012-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2012 IEEE 2nd Portuguese Meeting in Bioengineering (ENBENG)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ENBENG.2012.6331364","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
The conformational changes and aggregation of amyloid β peptide (Aβ) are associated to Alzheimer's disease (AD). The aim of this work is to study the structure and fibril assembly of Aβ in the presence of charged and nonionic amphiphiles, and β-sheet breaker peptides/conjugates. It is expected that these molecules will inhibit Aβ aggregation. Liposome systems will be developed as carriers for these peptide conjugates to cross the brain blood barrier (BBB).
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