Efectividad y seguridad de la combinación escina/procianidina en la insuficiencia venosa crónica

Abstract

Introduction

Chronic venous insufficiency is a disease that affects 20-30% of the adult population, reaching 50% in the population over 50 years. The lifestyle, hours in standing, diet and genetic factors improve the development of symptoms such as heaviness, pain or swelling of the lower limbs, as well as varicose veins.

Objective

To demonstrate the beneficial effects of the escine + procyanidine association in patients with chronic venous insufficiency assessing the changes in the patients treated by quality of life questionnaires and determining the safety.

Methodology

Prospective and longitudinal study in patients diagnosed with chronic venous insufficiency. Patients were randomly in 2 groups, usual care and the escine + procyanidine complex.

To measure results, the questionnaires SF-36v2 and VEINES-QOL/SYM were used, comparing the beginning with the end of the study. In order to measure the clinical relevance, the index denominated “d” of Cohen was calculated and used. The analysis was made by intention to treat.

Results and conclusions

In the escine + procyanidine complex patients the VEINES-SYM questionnaire indicated a significant improvement in the parameters “swollen legs”, “night cramps”, “heat/burning” and “restless legs” with respect to the Usual Care group.

Results

showed that the escine + procyanidine complex is safe, no significant differences were detected compared to the usual care group.