The role of estrogen, androgen and progestogen receptors in the management of carcinoma of the prostate.

J D Young, S M Sidh, N Bashirelahi
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Abstract

Identification of specific 17-beta-estradiol, 5-alpha-dihydrotestosterone and progesterone binding proteins in 10 patients with metastatic adenocarcinoma of the prostate is presented. A synthetic androgen radioligand (R1881) and a synthetic progesterone (R5020) were used. In all but 1 patient receptor protein assays were done before hormonal manipulation. Based on the preliminary findings it seems probable that prostatic carcinoma might be categorized for endocrine therapy similar to the method used for carcinoma of the breast.

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雌激素、雄激素和孕激素受体在前列腺癌治疗中的作用。
本文报道了10例前列腺转移性腺癌患者中特异性17- β -雌二醇、5- α -二氢睾酮和孕酮结合蛋白的鉴定。使用合成雄激素放射配体(R1881)和合成孕酮(R5020)。除1例患者外,其余患者均在激素操作前进行受体蛋白检测。根据初步的研究结果,前列腺癌可能会被归类为内分泌治疗,类似于乳腺癌的治疗方法。
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