Mitsuko A. Hanashiro, Maria Helena Da Silva , Otto G. Bier
{"title":"Neutralization of crotoxin and crude venom by rabbit antiserum to crotalus phospholipase A","authors":"Mitsuko A. Hanashiro, Maria Helena Da Silva , Otto G. Bier","doi":"10.1016/0161-5890(78)90103-7","DOIUrl":null,"url":null,"abstract":"<div><p>Rabbits were immunized with purified phospholipase A isolated by ion exchange chromatography from the venom of<em>Crotalus durissus terrificus</em>, a South American rattlesnake. As shown by<em>in vitro</em> and<em>in vivo</em> tests, the antiserum was able to neutralize the hemolytic and toxic activities of the purified enzyme, as well as of crotoxin and the crude venom.</p></div>","PeriodicalId":13265,"journal":{"name":"Immunochemistry","volume":"15 10","pages":"Pages 745-750"},"PeriodicalIF":0.0000,"publicationDate":"1978-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-5890(78)90103-7","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunochemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0161589078901037","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 12
Abstract
Rabbits were immunized with purified phospholipase A isolated by ion exchange chromatography from the venom ofCrotalus durissus terrificus, a South American rattlesnake. As shown byin vitro andin vivo tests, the antiserum was able to neutralize the hemolytic and toxic activities of the purified enzyme, as well as of crotoxin and the crude venom.
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