Invitro studies of the effect of Bilharcid on urinary tract bacterial pathogens.

Abstract

The antimicrobial effect of an antibilharzial drug "Bilharcid" was tested, in vitro, against 51 different strains of bacterial species frequently causing urinary tract infection namely E. coli, Staphylococcus aureus, klebsiella, Ps. pyocyanea and Proteus vulgaris. In addition, the drug was tested against one strain of each of Salmonella typhi, Salmonella paratyphi A. B and C. Minimum inhibitory concentration (M.I.C.) of the drug for each organism, and its bactericidal concentration were determined. The amount of the drug excreted in urine of patients receiving labelled Bilharcid Sb 124, after 2, 6, 8 and 10 hr. of administration was determined. In this work, the amount of bilharcid excreted in urine/ml urine is below its M.I.C. for most bacterial species, examined.