[Effect of muscular activity and administration of amino acid mixture on protein synthesis in rat skeletal muscles].

Abstract

The mechanisms were studied determining the protein synthesis intensification in the skeletal muscles of albino rats during systematic physical activity only and in combination with enteroadministration of amino acid mixture. It is shown that systematic physical activity induces an increase in the RNA content in the skeletal muscles along with the lack of differences in specific radioactivity of microsomal, ribosomal and poly-A-containing mRNA. Supplementary administration of amino acid mixture in combination with the systematic physical activity induces a further increase in the skeletal muscle RNA content along with a decrease in specific radioactivity of poly-A-containing mRNA, parallel with an increase in its portion in microsomal RNA, as well as results in shifts of the ribosomal spectrum towards polysomal complexes.