The role of cryosurgery in external ocular and periocular disease.

F T Fraunfelder, T R Wallace, H E Farris, J Watkins, R Hendrickson, W J Smead, B L Limmer
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Abstract

This preliminary report suggests that cryosurgery has a definite place in the management of certain external periocular and ocular problems. Cryosurgery for basal or squamous cell carcinoma of the lid is easily performed, gives excellent cosmetic results, and has a low recurrence rate. It is not recommended for lesions involving the fornices, or sclerotic and morphea-type basal cell carcinomas. Tumor recurrences following radiation, surgery, or cryosurgery can still be retreated with cryosurgery. To date, there is no evidence that cryosurgery at temperatures above -40 C causes damage to the lacrimal outflow system. Cryosurgery is of value in the management of trichiasis, reactive lymphoid hyperplasia, spider hemangioma, molluscum contagiosum, and conjunctival dysplasia. Cryotherapy for management of intraepithelial epithelioma and squamous cell carcinoma of the conjunctiva and cornea is still under investigation. Cryosurgery will, in our opinion, become the treatment of choice for basal and squamous cell carcinomas of the eyelids. The 96% cure rate with one treatment for these lesions reported here is artificially high since the follow-up period is too short. However, retreatment with cryosurgery is a simple ten-minute outpatient procedure which is certainly not the case with recurrences after other forms of therapy.

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冷冻手术在眼外和眼周疾病中的作用。
这一初步报告表明冷冻手术在某些眼外和眼周问题的治疗中具有明确的地位。冷冻手术治疗眼睑基底细胞癌或鳞状细胞癌是一种简便、美观、低复发率的手术。不建议病变累及穹窿,或硬化型基底细胞癌。放疗、手术或冷冻手术后的肿瘤复发仍然可以通过冷冻手术治疗。到目前为止,没有证据表明在零下40摄氏度以上的温度下进行冷冻手术会对泪流系统造成损害。冷冻手术在倒睫、反应性淋巴增生、蜘蛛状血管瘤、传染性软疣和结膜发育不良的治疗中很有价值。冷冻疗法用于结膜和角膜上皮内上皮瘤和鳞状细胞癌的治疗仍在研究中。在我们看来,冷冻手术将成为眼睑基底细胞癌和鳞状细胞癌的首选治疗方法。由于随访时间太短,这里报道的一次治疗96%的治愈率是人为高的。然而,再治疗冷冻手术是一个简单的十分钟的门诊程序,这当然不是在其他形式的治疗后复发的情况。
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