[Oxidative phosphorylation in rat heart mitochondria under administration of hydrocortisone and insulin].

Abstract

The rate of oxidative phosphorylation was studied in heart mitochondria of rats which were administered hydrocortisone and then corticoid in combination with insulin. It is established that 5 h after a single administration of hydrocortisone oxidative phosphorylation increases slightly and is statistically insignificant. Injections of corticosteroids to animals for 14 days inhibit considerably the rate of oxidation and phosphorylation, cause a decrease in the values of respiratory control and APD/O coefficient. Administration of insulin simultaneously with hydrocortisone to animals normalizes these disturbances to a considerable extent.