[Cholesterol biosynthesis in stomach and intestinal tissue of rat].

Ukrains'kyi biokhimichnyi zhurnal Pub Date : 1977-09-01
J A Nikolenko, O F Perederij
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Abstract

Biosynthesis of cholesterol and its precursors (metastenol, latosterol and 7-dehydrocholesterol) was studied in the mucous and serous membranes of small intestine, secretory and esophageal regions of the normal rat stomach. The content of these sterols was also determined. The intensity of sodium 2-14C-acetate incorporation into cholesterol and its precursors in the mucous membrane of the small intestine and stomach secretory region is considerably higher than into the same sterols of the serous membrane and esophageal region. Cholesterol synthesis is most intensive in the small intestine mucous membrane and stomach secretory region.

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[大鼠胃肠组织中胆固醇的生物合成]。
研究了正常大鼠小肠、分泌区和食道区粘膜和浆膜中胆固醇及其前体(亚介醇、乳甾醇和7-脱氢胆固醇)的生物合成。测定了这些甾醇的含量。2- 14c -乙酸钠掺入小肠和胃粘膜分泌区胆固醇及其前体的强度要比掺入浆膜和食道区相同的固醇的强度高得多。胆固醇合成在小肠粘膜和胃分泌区最为密集。
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