Effects of H2 Receptor Blocking Agents on Bacterial Translocation in Burn Injury*

A. Avanoğlu1, Ö. Herek1, I. Ulman1, O. Ergün1, A. Tünger2, M. Alkanat3, A. Erdener1
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引用次数: 7

Abstract

We experimentally studied the effects of Hz receptor block ers (ranitidine) on bacterial translocation (BT) in 42 male albino rals. Sham group (Group I, n .. 12 rau) wert' exposed to 21"C water while Bum group (Groop 11, n" lS rats) and Ranitidine group (Group 11I. n - 15 ratsl were exposed to 95" C hot water for 10 seconds to produce a full thidmess burn in 30 % of total body surface area. 300 mglkg ranitidine was administered to Group 11I starting immediately after the burn injury. Rats were sacrtficed on the fifth postbum day. Sham group gained weight while groups 11 and 11I had significant weight loss. Gastric pH increased with the admin-Resume
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H2受体阻断剂对烧伤细菌易位的影响*
我们实验研究了Hz受体阻滞剂(雷尼替丁)对42例男性白化病患者细菌易位(BT)的影响。假手术组(第一组,n .…12只大鼠不暴露于21℃的水中,而烧伤组(11组,n组)和雷尼替丁组(11组)则不暴露于21℃的水中。将15只老鼠暴露在95摄氏度的热水中10秒钟,使30%的体表面积被完全烧伤。11I组烧伤后立即给予雷尼替丁300 mg / kg。在第五天处死大鼠。假手术组体重增加,而11、11I组体重明显减轻。胃pH值随给药而升高
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