The phacoemulsification procedure. I. The effect of intraocular irrigating solutions on the corneal endothelium.

Investigative ophthalmology Pub Date : 1976-06-01
B E McCarey, F M Polack, W Marshall
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Abstract

Irrigating solutions for intraocular purposes were evaluated for their possible damaging effects on the corneal endothelial cell structure and function. Rabbit corneal endothelium was perfused in vitro with Tis-u-Sol, Travenol Ringer's Solution, or Travenol Sodium Chloride. The irrigating solutions caused an immediate corneal swelling of 67 mum per hour +/- 5 (mean +/- standard error), which was not modified by a previous stabilization perfusion with glutathione-bicarbonate Ringer's (GBR). In contrast, the Plasma-lyte-148 solution which is used in the phacoemulsification procedure, did not cause corneal swelling for more than twenty minutes, and for more than sixty minutes if the cornea was perfused after a GBR stabilization. After more than sixty minutes of corneal swelling, endothelial intercellular junction separations appeared. This breakdown was present with the tested irrigating solutions except for Travenol Ringer's Solution, which contained calcium. Plasma-lyte was also evaluated in conjunction with the surgical phacoemulsification procedure. The complete procedure or just irrigation with ultrasound did not cause endothelial cell damage similar to a prolonged in vitro irrigation. Instead, endothelial cells were traumatically damaged in varying degrees by the surgical manipulations.

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超声乳化术。1 .眼内冲洗液对角膜内皮的影响。
我们评估了眼内冲洗液对角膜内皮细胞结构和功能的可能破坏作用。用Tis-u-Sol、曲凡诺林格氏液、曲凡诺氯化钠分别灌注兔角膜内皮。冲洗液立即引起角膜肿胀,每小时67 μ m +/- 5(平均+/-标准误差),先前用谷胱甘肽-碳酸氢盐林格(GBR)稳定灌注后没有改变。相比之下,用于超声乳化手术的血浆碱液-148溶液在超过20分钟内不会引起角膜肿胀,如果在GBR稳定后角膜灌注,则超过60分钟。角膜肿胀60多分钟后,内皮细胞间连接处出现分离。除了含有钙的Travenol林格氏溶液外,所测试的冲洗溶液都存在这种分解。血浆电解质也与外科超声乳化手术一起进行评估。与长时间体外冲洗相比,整个过程或仅用超声冲洗不会造成内皮细胞损伤。相反,内皮细胞在不同程度上受到手术操作的创伤性损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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