Effects of isoproterenol and norepinephrine on regional ocular blood flows.

Investigative ophthalmology Pub Date : 1976-06-01
A B Malik, W A van Heuven, L F Satler
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Abstract

The effects of norepinephrine and isoproterenol on regional ocular blood flows were studied by the labeled microspheres using the reference sample method in pigs. Total and regional ocular flows increased in response to norepinephrine and isoproterenol infusions. Increase in flows during norepinephrine infusion may be due to increased ocular perfusion pressure induced by the drug, thereby masking its reported direct vasoconstrictor effect in isolated perfused ocular vessels. Increase in flows during isoproterenol infusion occurred despite a decrease in arterial pressure suggesting the existence of vasodilatory beta-adrenergic receptors in the ocular circulation of the pig.

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异丙肾上腺素和去甲肾上腺素对眼部局部血流的影响。
用标记微球法研究了去甲肾上腺素和异丙肾上腺素对猪眼部局部血流的影响。去甲肾上腺素和异丙肾上腺素输注后,总眼流量和局部眼流量增加。去甲肾上腺素输注过程中血流增加可能是由于药物引起的眼灌注压升高,从而掩盖了其在离体灌注的眼血管中的直接血管收缩作用。在异丙肾上腺素输注期间,尽管动脉压降低,但血流增加,这表明猪的眼循环中存在血管舒张β -肾上腺素能受体。
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