Impact of Pharmacist Initiated Antimicrobial Stewardship Program ~Evaluation of Antimicrobial Resistance Rate at Three Years after Intervention~

Abstract

In Tama-Nanbu Chiiki Hospital, a pharmacist-initiated antimicrobial stewardship program was started to optimize the use of antimicrobial agents in the hospital. Previously, at 10 months after the start of the program, the therapy durations for both 4 th cephem and carbapenem were short-ened. However, at that time, the resistance rate of Pseudomonas aeruginosa for both agents did not markedly change. Currently, we evaluated the correlation between the resistance rate of Pseudomonas aeruginosa and above mentioned antibiotics at 3 years after intervention. Al-though the day of therapy (DOT) was almost the same as that at 10 months of intervention, we achieved decreased resistance of Pseudomonas aeruginosa for both antibiotics. A positive correlation was observed between 4 th cephem resistance rate in Pseudomonas aeruginosa and DOT (0.90, p = 0.04). To reduce the antimicrobial resistance rate, a longer period of intervention is recommended.