1016 IL-2 expanded tumor infiltrated Natural Killer (TINK) cells from canine sarcomas possess potent anti-tumor cytotoxicity

Abstract

Background Tumor infiltrating NK (TINK) cells are present and linked to prognosis in many solid tumors. 1 While these cells may have potent antitumor effector function, they are thought to be dysfunctional in the tumor microenvironment (TME). 2 Because it is difficult to culture potent TINKs from human tumors, relatively little is known about their interac-tions with various TME components or their potential for therapeutic applications. Here we report reproducible culture of highly potent TINKs from naturally occurring canine sarcomas for use in modeling the human TME.