Antipsychotics in bipolar depression: in reply

Abstract

Krishnadas & Livingston (2010) make the case for caution when interpreting the results of our meta-analysis showing the efficacy of some second-generation antipsychotics in bipolar depression, as well as their apparent rapid onset of action (Cruz et al. 2010). While we generally agree that in the case of olanzapine the only items that significantly separated from placebo were those assessing sleep, inner tension and appetite (Tohen et al. 2003) and this, plus the fact that the combination of olanzapine with fluoxetine was significantly superior to …