Duodenal Infusion of Donor Feces for Recurrent Clostridium Difficile

Abstract

Background Recurrent Clostridium dif fi cile infection is dif fi cult to treat, and failure rates for antibiotic therapy are high. We studied the effect of duodenal infusion of donor feces in patients with recurrent C. dif fi cile infection. Methods We randomly assigned patients to receive one of three therapies: an initial vancomycin regimen (500 mg orally four times per day for 4 days), followed by bowel lavage and subsequent infusion ofa solution ofdonor feces througha nasoduodenal tube; a standard vancomycin regimen (500 mg orally four times per day for 14 days); or a standard vancomycin regimenwith bowel lavage. The primary end point was the resolution of diarrhoea associated with C. dif fi cile infection without relapse after 10 weeks.