Rate-dependent effect of amphetamine in rats: extension to between-subjects effect.

M D Beecher, D E Jackson
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引用次数: 4

Abstract

Following either variable-interval or fixed-interval training. 20 rats received both 0.5 and 2.0 mg/kg of amphetamine. For both schedules, amphetamine decrease response rates of high-rate subjects and increased those of low-rate subjects. Within-subject analysis of fixed-interval rates revealed the same rate-dependent effect. It is suggested that the between-subject and within-subject effects may have the same basis.

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安非他明对大鼠的速率依赖效应:扩展到受试者间效应。
进行可变间隔或固定间隔训练。20只大鼠分别给予0.5和2.0 mg/kg的安非他明。安非他明降低高反应率受试者的反应率,提高低反应率受试者的反应率。固定间隔率的受试者内分析显示了相同的速率依赖效应。研究表明,主体间效应和主体内效应可能具有相同的基础。
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Biochemical background for clinical drug effect Long term effects of psychotropic drugs Social implications of psychopharmacology Straiatum and neuroleptics Biochemical findings in mental illness. Affective disorders
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