Low Carbohydrate Lifestyle Reduces Significantly Insulin Need in Type 2 Diabetes Patients

H. Verkoelen, E. Govers, H. Maas, Koek Gh
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Abstract

A low carbohydrate diet is suggested to be effective in type 2 diabetes to reduce or stop glucose lowering medication. To prove the effectiveness of this dietary change, a low carbohydrate diet was studied in patients with type 2 diabetes on the amount of insulin, HbA1c values and weight loss. Methods An observational study in one dietitian practice on the treatment of patients with type 2 diabetes, all on an insulin regimen, with a low carbohydrate diet. Two HbA1c values prior to, and after six months of the dietary intervention were measured. All patients received a dietary advice to consume 30 grams carbohydrates per day in a day menu schedule. Patients visited the outpatient clinic to discuss their results, experiences, and questions. The online treatment group received feedback every week and extra support per mail. Results We included 37 overweight type 2 diabetes patients on insulin treatment and evaluated 35 patients after 6 months. The consumption of carbohydrates was 31±10 grams per day. Insulin use was reduced significantly (p<0.001) from 62.6±46.4 IU to 1.4±6.4 IU per day. For 92% of the participants, insulin injections could be stopped completely. Patients lost a mean of 13.3±6.3 kg of weight and the mean HbA1c level declined from 63.4±11.0mmol/mol to 56.9±13.0mmol/mol (p<0.001). Conclusion A low carbohydrate dietary lifestyle is effective in improving HbA1c and weight loss and leads to a significant reduction of insulin need.
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低碳水化合物生活方式显著降低2型糖尿病患者胰岛素需求
低碳水化合物饮食被认为是有效的2型糖尿病患者减少或停止降糖药物。为了证明这种饮食改变的有效性,我们在2型糖尿病患者中研究了低碳水化合物饮食对胰岛素量、HbA1c值和体重减轻的影响。方法对1例低碳水化合物饮食治疗胰岛素治疗2型糖尿病患者进行观察性研究。测量饮食干预前和干预后6个月的两个HbA1c值。所有患者都接受了饮食建议,每天摄入30克碳水化合物。病人到门诊讨论他们的结果、经验和问题。在线治疗组每周都会收到反馈,每封邮件都会得到额外的支持。结果纳入37例接受胰岛素治疗的超重2型糖尿病患者,并在6个月后对35例患者进行评估。碳水化合物的摄入量为31±10克/天。胰岛素使用量显著降低(p<0.001),从每天62.6±46.4 IU降至1.4±6.4 IU。92%的参与者可以完全停止注射胰岛素。患者平均体重减轻13.3±6.3 kg,平均HbA1c水平从63.4±11.0mmol/mol降至56.9±13.0mmol/mol (p<0.001)。结论低碳水化合物饮食生活方式可有效改善HbA1c和减轻体重,并可显著降低胰岛素需求。
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