E-091 Outcome following mechanical thrombectomy for anterior circulation large vessel occlusion stroke in octogenarians and nonagenarians compared to younger age

Abstract

able. Clot porosity enables continuous fluid flow, which results in drag forces on the solid elements of the network that promote ingestion. Clot permeability is closely related to clot perviousness, which is a measure of contrast agent accumulation within clots, detectable by computed tomography angiography. Moreover, clot perviousness is associated with first pass success with thrombectomy. Clot deformation also promotes clot ingestion into a narrow bore catheter. Benchtop data has demonstrated that clots can elongate from 20% to 100% prior to breakage. 5 Therefore, greater fluid flow during thrombectomy promotes greater clot ingestion through multiple mechanisms. Greater fluid flow can also promote more rapid clot ingestion during thrombectomy since the higher velocities convect clots faster during ingestion. Decreases in thrombectomy procedure time will reduce risk and post-procedure complications. New benchtop experimental and pre-clinical data will be presented that support the relevance of these mechanical mechanisms of effective blood clot removal in neurovascular applications.