Serum immunoglobulin levels in White and Black patients with virus-A and-B hepatitis.

T Ipp, G M Macnab, R Sher, M C Kew
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Abstract

Serum immunoglobulin G, M and A levels were measured in 106 White patients with acute virus-A (hepatitis-B surface antigen-negative) hepatitis and 27 White patients with acute virus-B (hepatitis-B surface antigen-positive) hepatitis and compared with the values previously obtained in Black patients with these diseases. The mean serum IgM level in the White patients with virus-A hepatitis was significantly higher than that in virus-B hepatitis (p less than 0,001). This difference was much more obvious than that in Black patients, mainly due to a much lower mean serum IgM response in Black patients with virus-A hepatitis. The reason for the blunted IgM response in Black patients with virus-A hepatitis is not known, but it may be related to a difference in the reaction against altered host tissues rather than any difference in antibody production against the virus per se. The mean serum IgG and IgA levels were not significantly different in the White patients with virus-A and virus-B hepatitis and they were lower than the corresponding figures in Blacks.

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甲型肝炎和乙型肝炎白人和黑人患者血清免疫球蛋白水平的变化
本文测定了106例白人急性甲型肝炎(乙型肝炎表面抗原阴性)患者和27例白人急性乙型肝炎(乙型肝炎表面抗原阳性)患者的血清免疫球蛋白G、M和A水平,并与黑人患者的血清免疫球蛋白G、M和A水平进行比较。白种人a型肝炎患者血清IgM水平显著高于b型肝炎患者(p < 0.001)。这种差异比黑人患者明显得多,主要是由于黑人a型肝炎患者的平均血清IgM反应要低得多。黑人a型肝炎患者IgM反应减弱的原因尚不清楚,但这可能与对改变的宿主组织的反应不同有关,而不是与针对病毒本身的抗体产生的任何差异有关。白人甲肝和乙型肝炎患者血清IgG和IgA水平差异无统计学意义,低于黑人。
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