Left Ventricular Hypertrophy in Obese Children

Abstract

Childhood obesity is one of the most troubling health conditions worldwide, and it is associated with many diseases that eventually lead to serious morbidities and mortality in adulthood, such as insulin resistance, type 2 diabetes mellitus, high blood pressure, dyslipidemia, obstructive sleep apnea and subsequent renal, and liver and cardiovascular diseases. Cardiovascular disease carries the most risk of all of the long-term outcomes of obesity because it is associated with serious complications in adult life, such as heart failure, acute coronary syndrome, and premature sudden death. This review aims to address childhood obesity as a worldwide health concern and focuses on the cardiovascular risk and adverse outcomes associated with this condition. This review presents details of obesity-related cardiac structural and functional changes, such as left ventricular hypertrophy (LVH) and dysfunction, respectively. A search of multiple medical databases was performed, and the results yielded many studies related to pediatric left ventricular hypertrophy; seventeen studies were found on left ventricular hypertrophy in obese children from 1980 to 2015. Most of these studies demonstrated that obesity and its comorbidities are important predictors for left ventricular hypertrophy in the pediatric age group. Furthermore, weight reduction is an important measure to reverse these structural changes and reduce the associated risks.