2-Carbamyl-9-[Beta-D-Ribofuranosyl] hypoxanthine from Rambutan fruit as potential inhibitor of apoptotic proteins:In silico molecular docking approach

Abstract

The fruit of the rambutan tree, Nephelium lappaceum, is an important source of physiologically active substances that have the ability to induce apoptosis. Because of this, the goal of the current work was to anticipate how the GC-MS spectrum compound from Nephelium lappaceum (2-Carbamyl-9-[Beta-D-Ribofuranosyl] Hypoxanthine]) would interact with apoptotic proteins (Caspase-3, Caspase-9, -Actin, p53, and Bcl-2) using the PatchDock docking program. As a result of the Lipinski rule, 2-Carbamyl-9-[Beta-D-Ribofuranosyl] Hypoxanthine is recommended as the best cancer treatment. The use of a molecule as a potential natural medicinal agent to treat disease is demonstrated through docking studies.