Effect of tissue temperature and radiation parameters on the quantum efficiency of photodissociation of oxyhemoglobin in cutaneous blood vessels

Abstract

In the present work we have investigated the in vivo effect of tissue temperature and laser parameters on the quantum efficiency of laser-induced photodissociation of oxyhemoglobin (HbO2) in cutaneous blood vessels by measuring the change in the oxygen saturation of arterial blood. Arterial oxygen saturation (SaO2) was measured using the method of fingertip pulse oximetry. It is shown that there is a local decrease in the local oxygen saturation upon laser irradiation by approximately 10% . Raising the local temperature of the skin tissue up to 42°C leads to an increase in the quantum efficiency of the photodissociation of HbO2 by approximately 1,5% upon irradiation with a wavelength of 860 nm. The obtained results can be used in the clinical phototherapy practice.