Epigenomics and the Xenoformed Earth: Bioinformatic Ruminations with Gilbert Simondon

William R. Morgan
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Abstract

A quiet revolution in genetics is increasingly rendering our milieu strange and artificial. Epigenomics, informatic cousin of epigenetics, is a xenoforming process, giving birth to an alien milieu, replacing the natural with the technical. If epigenetics is understood as the heritable changes in gene expression that do not alter DNA sequence, epigenomics takes as object the set of epigenetic modifications. Environmental, social, even political aspects of life’s variability are re-understood digitally in epigenomic profiles, the previous categories computationally accounted for as potential triggers of epigenesis. Following Gilbert Simondon, the xenoforming procedures of epigenomics can be understood as the concretization and adaptation processes of a technical object, the invention of which gives birth to a technogeographic milieu. In this article, the author examines Simondon’s work, especially, ‘On the Mode of Existence of Technical Objects’, alongside contemporary scholarship on epigenetics.
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表观基因组学和异种地球:与吉尔伯特·西蒙顿的生物信息学反思
一场悄无声息的遗传学革命正日益使我们的环境变得奇怪和人造。表观基因组学是表观遗传学的信息学表亲,是一种异种形成的过程,产生了一个陌生的环境,用技术取代了自然。如果表观遗传学被理解为不改变DNA序列的基因表达的可遗传变化,那么表观基因组学则以一系列表观遗传修饰为对象。环境、社会、甚至政治方面的生命可变性在表观基因组图谱中被数字化地重新理解,之前的类别被计算为表观遗传的潜在触发因素。按照Gilbert Simondon的观点,表观基因组学的异种形成过程可以理解为技术对象的具体化和适应过程,技术对象的发明产生了技术地理环境。在这篇文章中,作者考察了西蒙顿的工作,特别是“关于技术对象的存在模式”,以及当代表观遗传学的学术研究。
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