Observations on polycythemia vera turning into acute or chronic granulocytic leukemia during treatment with radioactive phosphorus 32P.

W Krańik
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Abstract

In a group of 172 cases of polycythemia vera treated with radioactive phosphorus acute granulocytic leukemia developed in 3 and chronic granulocytic leukemia in 6 cases. The author believes that development of acute granulocytic leukemia during this treatment may be considered with some probability as a result of the leukemia-inducing action of ionizing radiation. Transition of polycythemia vera into chronic granulocytic leukemia seems to be a natural outcome of this complex myeloproliferative syndrome in patients with survival prolonged by treatment with 32P.

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放射性磷32P治疗真性红细胞增多症转为急慢性粒细胞白血病的观察。
放射性磷治疗真性红细胞增多症172例,急性粒细胞性白血病3例,慢性粒细胞性白血病6例。作者认为,在此治疗过程中,有可能由于电离辐射的致白血病作用而导致急性粒细胞白血病的发生。真性红细胞增多症转变为慢性粒细胞白血病似乎是这种复杂骨髓增生综合征在32P治疗后延长生存期的患者的自然结果。
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