Extensive bilateral anterior and posterior circulation ischemic stroke caused by severe vasospasm (Delayed cerebral ischemia) due to aneurysmal subarachnoid haemorrhage (aSAH) - A case report

S. Balaji, S. Venkatesan
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Abstract

Aneurysmal subarachnoid haemorrhage (aSAH) is a disease with high morbidity and mortality even in this modern era. Since treating vasospasm is a challenging task, we emphasize in developing newer aganets for the treatment of vasospasm. In the hyper acute phase, patients with SAH can have catecholamine surge-related arrhythmia, neurogenic pulmonary edema, and irreversible damage to the hypothalamus and brainstem. Delayed cerebral ischemia (DCI) is a serious complication of aneurysmal subarachnoid haemorrhage (aSAH). Though there are many clinical trials to look upon the therapies for DCI and vasospasm in aSAH, none have led to an improvement in outcome of the patient.The prognosis of patients with SAH is grave even with the recent advancements in medical treatments. One of the main cause for this situation, that there are no usable neuroprotective drugs that can be used as soon as SAH is diagnosed. We report a case of ruptured Post Communicating Artery (PCOM) aneurysm with diffuse SAH causing severe vasospasm leading to extensive bilateral anterior and posterior ischemic stroke causing severe morbidity. Since there is no therapeutic breakthrough in treatment of aneurysmal SAH, we emphasize in developing a same.
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动脉瘤性蛛网膜下腔出血(aSAH)引起严重血管痉挛(延迟性脑缺血)引起的广泛双侧前后循环缺血性卒中1例报告
动脉瘤性蛛网膜下腔出血(aSAH)是一种高发病率和死亡率的疾病,即使在当今时代。由于治疗血管痉挛是一项具有挑战性的任务,我们强调开发治疗血管痉挛的新药物。在超急性期,SAH患者可出现儿茶酚胺手术相关的心律失常、神经源性肺水肿以及下丘脑和脑干的不可逆损伤。延迟性脑缺血(DCI)是动脉瘤性蛛网膜下腔出血(aSAH)的严重并发症。虽然有许多临床试验来研究aSAH中DCI和血管痉挛的治疗方法,但没有一项能改善患者的预后。即使在最近的医学治疗进展下,SAH患者的预后仍然很严重。造成这种情况的主要原因之一是,一旦诊断出SAH,就没有可用的神经保护药物可以使用。我们报告一例交通后动脉(PCOM)动脉瘤破裂并弥漫性SAH引起严重的血管痉挛,导致广泛的双侧前后缺血性卒中,并导致严重的发病率。由于在动脉瘤性SAH的治疗上没有治疗上的突破,我们强调发展一种相同的治疗方法。
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