The delayed luminescence spectroscopy as tool to investigate the cytotoxic effect on human cancer cells of drug-loaded nanostructured lipid carrier

R. Grasso, M. Gulino, A. Scordino, F. Musumeci, A. Campisi, R. Bonfanti, C. Carbone, G. Puglisi
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引用次数: 5

Abstract

The first results concerning the possibility to use Delayed Luminescence spectroscopy to evaluate the in vitro induction of cytotoxic effects on human glioblastoma cells of nanostructured lipid carrier and drug-loaded nanostructured lipid carrier are showed in this contribution. We tested the effects of nanostructured lipid carrier, ferulic acid and ferulic acidloaded nanostructured lipid carrier on U-87MG cell line. The study seems to confirm the ability of Delayed Luminescence to be sensible indicator of alterations induced on functionality of the mitochondrial respiratory chain complex I in U-87MG cancer cells when treated with nanostructured lipid carriers.
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用延迟发光光谱法研究载药纳米结构脂质载体对人癌细胞的细胞毒性作用
这是第一个关于使用延迟发光光谱来评估纳米结构脂质载体和载药纳米结构脂质载体对人胶质母细胞瘤细胞体外诱导毒性作用的可能性的结果。研究了纳米结构脂质载体、阿魏酸和阿魏酸负载纳米结构脂质载体对U-87MG细胞株的影响。该研究似乎证实了延迟发光的能力,是纳米结构脂质载体处理后U-87MG癌细胞线粒体呼吸链复合体I功能改变的敏感指标。
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