Hypoglycemic Effect of Anthocleista djalonensis and Blighi unijugata

Abstract

Anthocleista Djalonensis A Chev and Blighia unijugata Baker were collected and fractionated using petroleum ether, chloroform and ethylacetate. Spectroscopic quantitative phytochemical analysis was carried out on the fractions and they were found to contain alkaloids, flavonoids, phenols and steroids while tannins were found in significant quantity. Cytotoxicity was carried out on the fractions the fractions and they were found to be active except AD-P, 41.0680/26.0345 µg/cm3 and AD-E, 41.0080/26.0345 µg/cm3 while BU-P was found to be the most active at 8.4095/15.0123 µg/cm3. Experimental animals were induced with diabetes using streptozotocin and treated with the active fractions, BU-C 250mg dosage was found to have reduced glucose sugar level from 21.68 ±1.54 mmol/l in the first week to 3.16 ±1.05b mmol/l while BU-C 500mg dosage was found to increase weight from 112.8 ±53.2mg to in the first week to 140.2 ±9.4bg in the second week of intervention. The presence of phytochemicals, non-toxicity and being able to reduce glucose sugar in experimental animals by Blighia unijugata Baker chloroform fraction of makes a potential plant for treatment of diabetes.