Audit

A. Phillips
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Abstract

SUMMARY This audit was designed to assess whether existing UK vaccination programmes mean that patients receiving chemotherapy are being vaccinated against influenza. One hundred and ten adult patients receiving chemotherapy at a south London tertiary referral centre were interviewed when they attended for their chemotherapy. Thirty-six of the 110 (33%) patients had received their influenza vaccination at the time of the study. Vaccination rates were significantly higher in those patients older than 65 years (53% vs 17%, p<0.001), and in those with co-morbidities (49% vs 25%, p<0.05). The vaccination rate in this at-risk population is lower than the overall national uptake in those aged 65 and over. Those patients most likely not to receive their influenza vaccination are those who have no indication for vaccination other than the fact they are receiving chemotherapy. Increased awareness of the benefits of influenza vaccine and its safety is needed among general practitioners, patients and oncologists. (Int J Clin Pract 2003; 57(6): 542-543) P atients who are receiving cytotoxic chemotherapy for malignant disease are at increased risk of contracting influenza, which may be complicated by prolonged morbidity and increased risk of death. 1-5 North American and British guidelines therefore recommend annual vaccination against influenza for adults and children who are immuno suppressed because of disease or treatment. 6·' Available data show that influenza vaccines are well tolerated in patients receiving chemotherapy. However, the rates of sero conversion and the degree of clinical protection may be inferior to those seen in immunocompetent patients. 8 Other indications for influenza vaccination in the UK include chronic respiratory, cardiac or renal disease, diabetes mellitus, age 65 years and over, or patients living in long stay nursing or residential homes. In some areas vaccination has been recommended for all patients aged 50
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本次审核旨在评估英国现有的疫苗接种计划是否意味着接受化疗的患者正在接种流感疫苗。在南伦敦三级转诊中心接受化疗的110名成年患者在接受化疗时接受了采访。110名患者中有36名(33%)在研究期间接种了流感疫苗。65岁以上患者的疫苗接种率(53%对17%,p<0.001)和合并疾病患者的接种率(49%对25%,p<0.05)显著较高。这一高危人群的疫苗接种率低于全国65岁及以上人群的总体接种率。那些最有可能不接种流感疫苗的患者是那些除了正在接受化疗之外没有任何接种指征的患者。全科医生、患者和肿瘤学家需要提高对流感疫苗的益处及其安全性的认识。(国际临床医学杂志2003;57(6): 542-543 (P)因恶性疾病而接受细胞毒性化疗的患者感染流感的风险增加,这可能因长期发病和死亡风险增加而复杂化。因此,北美和英国的指南建议因疾病或治疗而免疫抑制的成人和儿童每年接种流感疫苗。现有数据显示,接受化疗的患者对流感疫苗耐受良好。然而,血清转化率和临床保护程度可能不如免疫功能正常的患者。在英国,流感疫苗的其他适应症包括慢性呼吸道疾病、心脏或肾脏疾病、糖尿病、65岁及以上的患者,或住在长期护理或寄宿家庭的患者。在一些地区,已建议所有50岁以上的患者接种疫苗
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