Controlled drug release from dental obturation cements

J. Tiago, A. P. Serro, M. G. Moutinho
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Abstract

The main purpose of this work is to investigate the release of antibiotics incorporated in dental obturation cements. It constitutes a first approach to the development of a type of drug delivery system with great interest and potential, that still is practically inexistent in the market. Several antibiotics and root canal sealers (RCS) were pretested through microbiological and dissolution tests, respectively in order to select the system(s) to study. Ampicillin was chosen to be incorporated in two commercial RCS, AH Plus® and EndoREZ®. The drug release kinetics was evaluated by high performance chromatography (HPLC) as a function of drug load and film thickness, and its microbiological efficacy after release was proven. For both sealers, ampicillin release occurred in the first few hours and depends on the drug load and film thickness. The relative amount released from EndoREZ® was higher, due to its higher hydrophilicity and porosity.
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牙封闭水泥药物释放控制
本研究的主要目的是研究牙封闭水泥中抗生素的释放情况。它构成了开发一种具有巨大兴趣和潜力的药物输送系统的第一种方法,这种系统在市场上实际上仍然不存在。分别通过微生物学和溶出度测试对几种抗生素和根管密封剂进行预测试,以选择要研究的系统。氨苄西林被选择纳入两个商业RCS, AH Plus®和EndoREZ®。采用高效液相色谱法(HPLC)对药物的释放动力学进行了表征,并考察了其释放后的微生物效应。对于两种封口处,氨苄西林释放发生在最初的几个小时,并取决于药物负荷和薄膜厚度。EndoREZ®的相对释放量更高,因为它具有更高的亲水性和孔隙度。
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