{"title":"Diagnosis of Porphyria after Sternotomy for Severe Calcific Coronary Artery Disease : A Case Report","authors":"Fuad M. Al-Azzam, S. Altarabsheh, M. Khasawneh","doi":"10.5742/MEIM.2017.92937","DOIUrl":null,"url":null,"abstract":"Acute intermittent porphyria (AIP) is an autosomal disorder marked by a deficiency of the enzyme, the hydroxymethylbilane synthase which is part of the heme biosynthesis. It is manifested clinically by multi-system involvement. Our patient does have chronic ischemic heart disease needed surgical revascularization; his sternotomy incision revealed the classical blackish discoloration of the bone marrow, which guided us for his work up and diagnosis.","PeriodicalId":243742,"journal":{"name":"Middle East Journal of Internal Medicine","volume":"432 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Middle East Journal of Internal Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5742/MEIM.2017.92937","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Acute intermittent porphyria (AIP) is an autosomal disorder marked by a deficiency of the enzyme, the hydroxymethylbilane synthase which is part of the heme biosynthesis. It is manifested clinically by multi-system involvement. Our patient does have chronic ischemic heart disease needed surgical revascularization; his sternotomy incision revealed the classical blackish discoloration of the bone marrow, which guided us for his work up and diagnosis.
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