Preliminary characterization of the external proton beam from a PET cyclotron for use in neutron and proton radiobiology and other dosimetric studies

S. Ghithan, H. Simões, F. Alves, S. Carmo, M. Cunha, R. Marques, F. Fraga, M. Pinto, P. Crespo
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引用次数: 7

Abstract

Different cyclotron models capable of accelerating protons up to 20MeV have been worldwide installed. Although their purpose is mainly positron emission tomography (PET) radioisotope production, they are equipped with several beam lines suitable for scientific research. Each beam line may typically deliver proton currents up to 150 μA (1×1015 particles/s). Radiobiological and dosimetric studies can be performed using these beam lines, which may contribute to further improve ion therapy and material radiation hardness results, among other applications. We report experimental results aiming at characterizing the proton beam achievable outside a PET cyclotron. In addition, we simulate this experimental setup by using Geant4. We show that simulation is consistent with previous published experimental data and with our first-measured results. These point to a beam angular spreading which may be utilized to establish an irradiation setup within the bunker. We estimate that the dose achievable with such setup may span 4-orders-of-magnitude, useful in radiobiology, ranging from 10mGy to 100 Gy. Finally, we show by simulation that neutron and γ-ray dose on a realistic, in-bunker target is negligible down to at most the 1% level. Further quantification for lower levels is ongoing.
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用于中子和质子放射生物学和其他剂量学研究的PET回旋加速器外部质子束的初步表征
世界各地已经安装了不同的回旋加速器模型,能够将质子加速到20MeV。虽然它们的目的主要是生产正电子发射断层扫描(PET)放射性同位素,但它们配备了几条适合科学研究的束流线。每个束流线通常可以提供高达150 μA (1×1015粒子/秒)的质子电流。使用这些束流线可以进行放射生物学和剂量学研究,这可能有助于进一步改善离子治疗和材料辐射硬度结果,以及其他应用。我们报告了旨在表征PET回旋加速器外可实现的质子束的实验结果。此外,我们还使用Geant4模拟了这个实验设置。我们表明,模拟与先前发表的实验数据和我们的首次测量结果是一致的。这些指向一束角扩散,可用于在掩体内建立辐照装置。我们估计,这种装置可达到的剂量可能跨越4个数量级,在放射生物学中有用,范围从10mGy到100gy。最后,我们通过模拟表明,中子和γ射线剂量对一个现实的,在掩体内的目标是可以忽略不计的,最高可达1%的水平。对较低水平的进一步量化正在进行中。
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