Multiple Micronutrients (vitamins E, C, beta-carotene) Intervention to Immunomicronutrients deficient Drug Addicts

Abstract

Background: The study has conducted on immunodeficient drug addicts. They were supplemented with immnunoenhancer antioxidant micronutrients aiming to improve the immunity. Method: Fifty immunodeficient drug addicts (IgG-deficient with impaired immune cells) were supplemented with vitamins E, C and β-carotene for 60 days. Twentyfive immunodeficient addicts treated as placebo control. Immunoglobulins and immune cells profile were analyzed before and on completion of micronutrients intervention. BMI of the study subjects were also assessed. Results: Supplementation of vitamin E, C and beta-carotene to the immnunodeficient drug addicts had significantly (p<0.05) increased BMI (18.3±2.4 vs 19.5±1.9), serum IgG (4.85±0.46g/L vs 6.06±0.65g/L), lymphocytes (60.2±19.5 vs 68.4±13.6), eosinophils (6.6±3.7 vs 7.8±5.9), but had decreased IgM (1.33±0.38 g/L vs 1.18±0.27g/L), monocytes (6.5±4.1 vs 5.2±2.3) and neutrophils (126.4±19.8 vs 118.5±16.2). BMI or immune components did not apparently alter in the placebo group during this 60 days period. However, compared to the placebo control group, supplementation of the micronutrients resulted in a significant (p<0.05) increase of IgG (6.06±0.65 g/L vs 5.04±0.40g/L), lymphocytes (68.4±13.6 vs 57.3±9.8), eosinophils (7.8±5.9 vs 6.1±2.3), but a decrease of IgM (1.18±0.27g/L vs 1.40±0.27g/L in the interventional group. Conclusion: Supplementation of immunoenhancing antioxidant vitamin E, C and β-carotene to immunodeficient subject upregulates immunity.