Effect of aflatoxin B1 on lipids of rat tissues.

N Singh, T A Venkitasubramanian
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Abstract

The effect of aflatoxin B1 on lipids of liver, kidney, adipose and plasma of rats was studied. A single dose administration (6 mg/kg body weight) increased liver and kidney weights and their total lipids within 24 h. Increase in liver lipids was confined mainly to phospholipid and cholesterol, whereas triglycerides showed a significant decrease. Adipose tissue triglycerides were, however, increased. Plasma showed decreases in triglycerides, free fatty acids and cholesterol. Incorporation studies with palmitate-1-14C revealed increased incorporation in adipose tissue lipids and decreased incorporation in liver and plasma lipids, thereby indicating an increased synthesis of lipids in adipose. Their mobilization to plasma was, however, inhibited, hence the low levels of triglyceride in liver. But the adrenals showed hypo-activity upon aflatoxin B1 administration.

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黄曲霉毒素B1对大鼠组织脂质的影响。
研究了黄曲霉毒素B1对大鼠肝、肾、脂肪及血浆脂质的影响。单剂量给药(6mg /kg体重)可在24小时内增加肝脏和肾脏的重量以及它们的总脂质。肝脏脂质的增加主要局限于磷脂和胆固醇,而甘油三酯则显著降低。然而,脂肪组织甘油三酯增加。血浆显示甘油三酯、游离脂肪酸和胆固醇降低。棕榈酸酯-1- 14c的掺入研究显示,脂肪组织脂质的掺入增加,肝脏和血浆脂质的掺入减少,从而表明脂肪中脂质的合成增加。然而,它们向血浆的动员受到抑制,因此肝脏中的甘油三酯水平较低。但黄曲霉毒素B1给药后,肾上腺活性降低。
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