MEMS based microstructure array design and its quantitative analysis of micropreconcentrator for cancer biomarker diagnosis

Naoki Kakita, H. Miyashita, S. Kishida, Sang-Seok Lee, Jeong-o Lee
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引用次数: 1

Abstract

We have proposed a high performance MEMS based microstructure array of micropreconcentrator (microPC) for breath diagnosis of cancer biomarkers. Moreover, we have reported in this paper for the first time the quantitative analysis results, which are used as evaluation criteria for determination of microstructure array performance. As a microstructure shape in microPC, we propose a flower leaf type shape. Owing to our new microstructure shape, biomarkers flow can be guided into microstructures and then contact area between biomarkers flow and microstructure surface can be maximized. The design parameters, such as shape, size and configuration of microstructures are studied and determined quantitatively by using particle adsorption model.
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基于MEMS微结构阵列的癌症生物标志物诊断微富集器设计及其定量分析
我们提出了一种基于MEMS微结构阵列的微预浓缩器(microPC),用于呼吸诊断癌症生物标志物。此外,我们还首次报道了定量分析结果,并将其作为确定微结构阵列性能的评价标准。作为微pc的微观结构形态,我们提出了花叶型形态。由于我们的微结构形状,生物标志物流动可以引导到微结构中,从而使生物标志物流动与微结构表面的接触面积最大化。采用颗粒吸附模型对微结构的形状、尺寸、构型等设计参数进行了研究和定量确定。
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