The Protective Role of Lycopene Against Oxidative Damage in the Liver, Heart and Kidney Tissues of Mice Exposed to CoCL2

Abstract

Heavy metals are harmful to both the environment and human health. One of these heavy metals is cobalt. Lycopene is a potent antioxidant. The purpose of this study was to investigate the effects of lycopene on change of lipid peroxidation in liver, kidney and heart of experimentally exposed mice with cobalt (Co). Experimental protocol: For this purpose, 30 Swiss Albino male mice of 3-4 months of age and weight ranging from 45 to 50 g were used. Mice were subdivided in to 3 groups including control, cobalt and cobalt lycopene (combined). The control group mice were given 3 mg/kg/day saline (by intramuscular injection) and 10 mg/kg/day saline (orally) for 30 days in order to achieve equality with administration to the mice in the experimental group). At the end of this process, malondialdehit (MDA), glutathione (GSH), vitamin-E and β -carotene were analyzed in the prepared homogenates. According to findings; Increase in liver MDA levels in cobalt group was significant (p 0.05). It was observed that liver and kidney β-carotene level in cobalt group was lower than control and combined group. This decrease is statistically significant in the kidney (p 0.05). As a result, increasing the antioxidant levels of GSH, vitamin E and β-carotene together with lycopene application may play an important role in preventing the negative effects of lycopene on free radicals (MDA, etc.) caused by acute cobalt oxidation