Overactive Bladder Management: Cognitive Risk With Anticholinergics and Alternative Management Options for the General Practitioner

Abstract

5-10 Given these new data, a focus on alternative oral medication treatments has emerged, including use of selective M2/M3 antagonists such as trospium and β -3 adrenergic agonists mirabegron and vibegron. 11-13 The American Geriatrics Society recently updated the Beers Criteria to include anticholinergic medications as a risk Overactive bladder (OAB) is a symptomatic condition characterized by urinary urgency, with or without incontinence, and is often associated with nocturia and increased frequency. 1 OAB is highly prevalent in the US adult population, affecting women and men similarly (16.9% and 16%, respectively). The prevalence of symptom type and severity, however, significantly differs by sex, with women noting urgency incontinence more frequently than men: 19.1% in women aged 65 to 74 years and 8.2% in men aged 65 to 74 years. 2 In women older than 65 years, the prevalence of OAB increases from 16% to 30%. 3 The hallmark physiologic abnormality responsible for OAB is detrusor overac-VOLUME