{"title":"Thermodynamic Measurements","authors":"","doi":"10.1002/9781119721789.ch11","DOIUrl":null,"url":null,"abstract":"When studying protein structure and function, it is essential to measure various physical quantities, including: – thermal and chemical stability – binding affinity to a ligand – solubility – dynamics and flexibility – reactivity One would like to predict thermodynamic properties from structure alone When two interacting molecules come together in water – solvent molecules are released from the binding surface – solute molecules form bonds (H-bonds, van der Waals contact, etc) – e.g. predict and tabulate all enthalpic and entropic changes","PeriodicalId":297279,"journal":{"name":"Metrology and Instrumentation","volume":"29 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Metrology and Instrumentation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/9781119721789.ch11","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
When studying protein structure and function, it is essential to measure various physical quantities, including: – thermal and chemical stability – binding affinity to a ligand – solubility – dynamics and flexibility – reactivity One would like to predict thermodynamic properties from structure alone When two interacting molecules come together in water – solvent molecules are released from the binding surface – solute molecules form bonds (H-bonds, van der Waals contact, etc) – e.g. predict and tabulate all enthalpic and entropic changes