Perinatal narcotic addiction in mice: sensitization to morphine stimulation.

Addictive diseases Pub Date : 1975-01-01
L Shuster, G W Webster, G Yu
{"title":"Perinatal narcotic addiction in mice: sensitization to morphine stimulation.","authors":"L Shuster,&nbsp;G W Webster,&nbsp;G Yu","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The injection of morphine sulfate into baby mice twice daily for 5 days increased their running reaponse to morphine when they were tested as adults. If treatment was completed before the mice were )5 days old there was no effect. Sensitization to morphine running was longer-lasting than either analgesic tolerance or tolerance to morphine running may be a form of denervation hypersensitivity that has several features in common with noise-induced sensitization to audiogenic seizures.</p>","PeriodicalId":75432,"journal":{"name":"Addictive diseases","volume":"2 1-2","pages":"277-92"},"PeriodicalIF":0.0000,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Addictive diseases","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

The injection of morphine sulfate into baby mice twice daily for 5 days increased their running reaponse to morphine when they were tested as adults. If treatment was completed before the mice were )5 days old there was no effect. Sensitization to morphine running was longer-lasting than either analgesic tolerance or tolerance to morphine running may be a form of denervation hypersensitivity that has several features in common with noise-induced sensitization to audiogenic seizures.

分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
小鼠围产期麻醉成瘾:吗啡刺激致敏。
对成年小鼠进行试验时,每天两次连续5天注射硫酸吗啡可增加小鼠对吗啡的奔跑反应。如果在小鼠5天大之前完成治疗,则没有效果。对吗啡运行的致敏比镇痛耐受更持久,或者对吗啡运行的耐受可能是一种去神经超敏的形式,它与噪声诱导的致敏对听源性癫痫有几个共同的特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
MIS use: alcoholism program experience. An accountability model for integrating information systems, evaluation mechanisms, and decision making processes in alcohol and drug abuse agencies. Evaluation and information systems. Use of information systems in the administration and evaluation of drug treatment programs. An information system for treatment evaluation in substance abuse.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1