General View of the Cytoplasmic and Nuclear Features of Apoptosis

Abstract

AIF apoptosis-inducing factor Apaf-1 apoptotic protease activating factor-1 ATP adenosine triphosphate BA bongkrekic acid Bcl-2 B-cell lymphoma-2 BID BH3-interacting domain death agonist bp base pair CAD caspase-activated DNase c-FLIP cellular FLICE-inhibitory protein Chx cyclohexamide CsA cyclosporine A CTL cytotoxic T lymphocyte cyt c cytochrome c DISC death-inducing signal complex DED death effector domain endo D endonuclease D endo G endonuclease G ER endoplasmic reticulum FADD Fas-associated death-domain protein FasL fatty acid synthetase ligand FasR fatty acid synthetase receptor Gzm-A granzyme-A Gzm-B granzyme-B ICAD inhibitor of caspase-activated DNase Kb kilobase MEF mouse embryonic fibroblast MOMP mitochondrial outer-membrane permeabilization NK natural killer OMM outer mitochondrial membrane PCD programmed cell death PFN Perforin