The topology of red cell membrane lipids in hereditary spherocytosis.

S S Zail, A K van den Hoek
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Abstract

The topology of membrane phospholipids in the red cells of patients with hereditary spherocytosis has been studied with the non-penetrating probe 2,3,5-trinitrobenzenesulphonate. There was no significant difference in the assymetric distribution of the aminophospholipids phosphatidylserine and phosphatidylethanolamine across the two halves of the membrane bilayer in red cells of five patients with hereditary spherocytosis as compared to seven normal controls. These studies indicated that the complex processes responsible for membrane lipid assymetry are intact in hereditary spherocytosis.

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遗传性球形红细胞增多症中红细胞膜脂质的拓扑结构。
用非穿透探针2,3,5-三硝基苯磺酸钠研究了遗传性球形红细胞病患者红细胞膜磷脂的拓扑结构。5例遗传性球胞增多症患者与7例正常对照相比,在两半膜双分子层上的氨基磷脂、磷脂酰丝氨酸和磷脂酰乙醇胺的不对称分布无显著差异。这些研究表明,负责膜脂不对称的复杂过程在遗传性球形红细胞增多症中是完整的。
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