Analysis of neurosteroid levels in attention deficit hyperactivity disorder.

R. Strous, B. Spivak, R. Yoran-Hegesh, R. Maayan, E. Averbuch, M. Kotler, R. Mester, Abraham Weizman
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引用次数: 77

Abstract

Neurosteroids are important neuroactive substrates with demonstrated involvement in several neurophysiological and disease processes. Attention deficit hyperactivity disorder (ADHD) has been associated with dysregulation of the catecholaminergic and serotonergic systems, however its relationship to irregularities or changes in neurosteroid levels remains unknown. We examined the relationship between blood levels of dehydroepiandrosterone (DHEA), its principal precursor pregnenolone and its principal metabolite dehydroepiandrosterone sulphate (DHEAS) in 29 young male subjects aged 7-15 years with DSM-IV criteria of ADHD. Subjects were evaluated by a specially designed scale, following which patients were divided into two groups according to severity of symptomatology. Results indicated significant inverse correlations between clinical symptomatology and levels of DHEA and pregnenolone in the total group. These inverse correlations were particularly evident in the less severe group of subjects. Levels of DHEA and DHEAS were inversely correlated with the hyperactivity subscale. Furthermore, using median blood levels as a cut-off indicator, higher blood levels of DHEA and DHEAS were associated with fewer ADHD symptoms, in particular hyperactivity symptomatology. Our findings suggest a possible protective effect of various neurosteroids on the expression of ADHD symptomatology.
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注意缺陷多动障碍患者神经类固醇水平分析。
神经类固醇是一种重要的神经活性底物,参与了多种神经生理和疾病过程。注意缺陷多动障碍(ADHD)与儿茶酚胺能和血清素能系统的失调有关,但其与神经类固醇水平的不规则或变化的关系尚不清楚。我们检测了29名年龄在7-15岁、伴有DSM-IV ADHD标准的年轻男性受试者血液中脱氢表雄酮(DHEA)、其主要前体孕烯醇酮及其主要代谢物硫酸脱氢表雄酮(DHEAS)水平之间的关系。采用专门设计的量表对受试者进行评估,然后根据症状严重程度将患者分为两组。结果显示,总组患者临床症状与DHEA、孕烯醇酮水平呈显著负相关。这些负相关在病情较轻的一组受试者中尤为明显。DHEA和DHEAS水平与多动症分量表呈负相关。此外,使用血液中位数水平作为截止指标,血液中DHEA和DHEAS水平越高,ADHD症状越少,尤其是多动症症状。我们的研究结果表明,各种神经类固醇可能对ADHD症状的表达有保护作用。
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