[Activities of molecules similar to carboxyhydroxamic acid chromone-2 (sodium salt) in experimental mercury chloride poisoning; importance of the chromone cycle].

L Fialip, M Payard, P Bastide, P Ralite, Y Teillard
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Abstract

The carbo-hydroxamic-2 chromone acid (sodium salt) shows a higher protective action in vivo than in vitro against mercury chloride induced intoxications. The higher effect observed in vivo might be due to the activity itself of the chromone cycle which added up to that of the carbo-hydroxamic acid function. This latter alone appears in vitro. The antihyaluronidasic properties of this protective agent allow it to prevent the toxic substances to be diffused.

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实验氯汞中毒中类似于羧羟肟酸-2(钠盐)分子的活性;染色体周期的重要性]。
碳-羟肟-2色素酸(钠盐)对氯化汞中毒的体内保护作用高于体外保护作用。体内观察到的较高效果可能是由于色素循环本身的活性加上碳-羟肟酸的功能。后者单独出现在体外。这种保护剂的抗透明质酸特性使它能够防止有毒物质扩散。
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