Influence of the combined method of air-plasma flows and NO-therapy on the blood system parameters in treatment of infectious wound complications in cardiac surgery

Abstract

Nitric oxide (NO) is a universal biological mediator that has a multifaceted effect on physiological and pathological processes in various organs and systems of the body. It is known that NO-therapy is a powerful stimulator of a positive effect on the course of the wound process, especially in complicated wounds.Objective: to evaluate the use of the combined effect of NO-containing air-plasma flows on the parameters of the blood system in the treatment of infectious wound complications in cardiac surgery patients.Materials and methods. A total of 60 patients were included in the study: 31 (52%) men and 29 (48%) women aged 29 to 79 years (mean 63.67 ± 7.6 years). All patients were divided into two groups: Group I – 30 patients who received treatment for sternomediastinitis using a combined exposure to air-plasma flow and exogenous nitric oxide; Group II – 30 patients who were treated for sternomediastinitis according to the clinical guidelines for the surgical treatment of patients with postoperative mediastinitis and osteomyelitis of the sternum and ribs.Results. The use of the combined effect of NO-containing air-plasma flows for the treatment of sternomediastinitis is accompanied by a decrease in the level of acute phase proteins already by 3 days, normalization of leukocytes and neutrophils by 10 days after the start of therapy, and prevents hyperaggregation and spontaneous aggregation of platelets.Conclusion. The use of the combined method of low-temperature plasma and exogenous nitrogen monoxide in the local treatment of infectious wound complications after cardiac surgery is justified and effective. No reliable confirmation of the cytotoxic effect of exogenous nitric oxide in the applied dosage on the elements of red blood was found in this study