Contemporary Literature Review of Clinical Characteristics and Management of Merkel Cell Carcinoma

{"title":"Contemporary Literature Review of Clinical Characteristics and Management of Merkel Cell Carcinoma","authors":"","doi":"10.37184/lnjcc.2789-0112.4.12","DOIUrl":null,"url":null,"abstract":"Merkel cell carcinoma is a rare aggressive, non-melanomatous cutaneous malignancy with rising incidence. It has two distinct etiologies Merkel cell polyomavirus associated and non-associated, usually presents as painless, indurated, solitary violaceous dermal nodules on sun-exposed sites, frequently in the head and neck region followed by extremities. The workup includes dermoscopy, histopathology with immunohistochemical staining, and imaging. Treatment modalities for Merkel cell carcinoma are surgery, radiation therapy, chemotherapy, etc. however, the role of immunotherapy and targeted agents is emerging.","PeriodicalId":363682,"journal":{"name":"Liaquat National Journal of Cancer Care","volume":"175 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Liaquat National Journal of Cancer Care","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37184/lnjcc.2789-0112.4.12","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract

Merkel cell carcinoma is a rare aggressive, non-melanomatous cutaneous malignancy with rising incidence. It has two distinct etiologies Merkel cell polyomavirus associated and non-associated, usually presents as painless, indurated, solitary violaceous dermal nodules on sun-exposed sites, frequently in the head and neck region followed by extremities. The workup includes dermoscopy, histopathology with immunohistochemical staining, and imaging. Treatment modalities for Merkel cell carcinoma are surgery, radiation therapy, chemotherapy, etc. however, the role of immunotherapy and targeted agents is emerging.
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梅克尔细胞癌临床特点及治疗的当代文献综述
默克尔细胞癌是一种罕见的侵袭性非黑色素瘤性皮肤恶性肿瘤,发病率呈上升趋势。它有两种不同的病因,默克尔细胞多瘤病毒相关和非相关,通常表现为无痛、硬化、孤立的紫色皮肤结节,多发于暴露在阳光下的部位,常见于头颈部,其次是四肢。检查包括皮肤镜检查、免疫组织化学染色组织病理学和影像学检查。默克尔细胞癌的治疗方式有手术、放疗、化疗等,但免疫治疗和靶向药物的作用正在兴起。
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